![]() ![]() Probing the probes: fitness factors for small molecule tools. Caloric restriction mimetics enhance anticancer immunosurveillance. Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk. This paper describes a new role for autophagy in sustaining pancreatic cancer by degrading MHC-I and promoting immune evasion.Ĭassidy, L. Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism. Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice. Selective autophagy and xenophagy in infection and disease. The role of autophagy in neurodegenerative disease. Autophagy-independent functions of the autophagy machinery. The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Molecular mechanism of autophagic membrane–scaffold assembly and disassembly. ULK–Atg13–FIP200 complexes mediate mTOR signaling to the autophagy machinery. Nutrient-dependent mTORC1 association with the ULK1–Atg13–FIP200 complex required for autophagy. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Biological functions of autophagy genes: a disease perspective. The coming of age of chaperone-mediated autophagy. Microautophagy: lesser-known self-eating. Cellular quality control by the ubiquitin–proteasome system and autophagy. Mechanism and medical implications of mammalian autophagy. Phase separation organizes the site of autophagosome formation. Molecular determinants of selective clearance of protein inclusions by autophagy. ![]()
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